Mitochondrial autophagy: eating yourself to - Dr Ian Ganley

Monday 15th June 2015

Mitochondrial autophagy: eating yourself to

Dr Ian Ganley

University of Dundee

When: Monday, 15 June, 2015 - 16:00

Where: Wolfson Lecture Theatre

The visiting speaker in the CVDM seminar series on Monday 15th June 2015 is Dr. Ian Ganley, Programme Leader at the University of Dundee. Dr Ganley obtained his undergraduate and Master’s degree in Biochemistry from the University of Oxford and, after working for one year at Oxford Glycosciences Ltd., moved to the University of Cambridge to undertake a Ph.D. in the laboratory of Dr Nick Ktistakis to work on the lipid hydrolase phospholipase D1. Ian then moved to California, where he carried out postdoctoral research with Professor Suzanne Pfeffer at Stanford University to decipher the role of Rab proteins in intracellular transport. It was during this time that Ian became interested in the key cellular process of autophagy and so joined the laboratory of Dr Xuejun Jiang at Memorial Sloan-Kettering Cancer Center in New York to understand this further. Ian relocated to Dundee in August 2010 to take up his position as a Programme Leader and continue his studies on autophagy in health and disease.

Abstract

Autophagy is a cell protective mechanism whereby unwanted, damaged or toxic cellular components are targeted to the lysosome for degradation and recycling. This essential process prevents the cell from ending up a rubbish dump, and because of this, impaired autophagy has been linked to many diseases including cancer, neurodegeneration and heart disease. The Ganley lab is interested in the signals that switch on autophagy and how these signals target specific cellular components. In this seminar I will focus on new tools we have developed to monitor the signals that target mitochondria for autophagic degradation.